Starvation Mode when you use Saxenda®. Myth or Truth.
Sometimes it's hard to know who or what to believe as there is often much conflicting advice! This leaves us confused and conflicted about which way to turn to in order to a healthier lifestyle. Episode 2 - All You Need to Know about Saxenda® I will attempt to address one question. Does Saxenda® cause your body to go into Starvation mode®?
Mention a Very Low-Calorie Diet and most people will immediately declare it will put your body into "starvation mode". Meaning your body will cling onto the fat and weight loss will be impossible. This usually makes me think well "if" it is true how do some people become anorexic or severely underweight? If it is true they wouldn't get so painfully thin. There would be no or very very few underweight people in the world, right?
The NHS has "U-turned" in its advice GPs are now able to prescribe Very Low-Calorie Diets in hope of reversing Diabetes.
One of the facts is to "lose weight" you will need to put your body in a calorie deficit. But then people worry their body will go into starvation mode. I am going to explain in laypersons terms how using Saxenda® does NOT put your body into starvation mode.
So let's begin with the facts
Saxenda® (Liraglutide) falls into the category of GLP-1 (glucagon-like peptide 1) agonist drugs. Liraglutide has its primary action over the glucagon peptide hormone.
Saxenda® sits on the cells and causes changes to the hormones of the body which are involved in regulating body weight: Insulin, Glucagon, and Leptin.
Role of GLP-1(glucagon-like peptide 1):
Liraglutide encourages the release of insulin. It also increases the volume of cells that produce beta cells in the pancreas. holding back the release of glucagon is also one of its functions. This reduces the cravings whilst directly acting on the appetite centre in the brain.
Originally, Liraglutide was developed for the treatment of type 2 diabetes because it helps to reduce insulin resistance. Later, people found that it has a dramatic effect on losing weight. After this, the makers of Liraglutide created the weight loss medication, brand name Saxenda®.
The most important attribute of this medication is that unlike the suppressant weight loss drug that works for a shorter duration, it can be used effectively for long-term chronic obesity management. Saxenda® imitates a hormone, which is already present in the body that compensates for the deficiency.
Let’s see how Saxenda works:
Reduce Leptin Resistance
A lot of people believe that the reason for weight gain and loss is the intake of excess calories alone. Much scientific research disagrees. Some scientists have pointed another factor for weight gain is a hormone, called "Leptin".
Being "resistant" to the effects of Leptin is believed to the reason of increased weight in humans. This hormone is produced by the body’s fat cells, often referred to as the "starvation hormone". Its primary target area is the hypothalamus.
This system evolved to keep us from overeating and starving, and its main role is enduring regulation of balanced energy, the number of calories we eat and the amount of fat stored in our bodies.
The GLP-1 agonists (which Liraglutide mimicks) help in lowering Leptin’s resistance. It might come as a shock for you to realise; when it comes to losing weight Leptin is the most important hormone that determines whether you will lose weight or not.
The way leptin works is relatively simple... (honest!)
The work of Leptin is fairly simple, as mentioned, this hormone is produced by the fat cells of the body, the higher the body fat, the more Leptin is produced.
Biologically, the hormone Leptin is carried by the bloodstream towards the brain, where the brain sends the signal to the hypothalamus region of the pituitary gland (this area controls when and how much an individual will eat).
With the help of Leptin, the fat cells notify the brain about the body fat they carry. When the excessive amount of Leptin is secreted, then it tells the brain that plenty of fat is stored, while a moderate amount of Leptin tells the brain that fat storage is low, resulting in starvation mode.
Saxenda® helps to reduce Leptin resistance and can also help to lower the Leptin levels.
So, how does Saxenda helps in Leptin resistance?
Saxenda® does two important things related to Leptin and Leptin resistance:
- It reduces the existing Leptin resistance, helping to change the functionality of the hormone by allowing the process of losing weight - we burn more.
- Once you have started losing weight, it attenuates the rise of Leptin resistance and helps you keep off the lost weight.
The figure above shows how Leptin and Leptin resistance works.
In Episode 3 - All You Need To Know About Saxenda ®, I will explain how Saxenda® improves Insulin Sensitivity and Insulin sensitivities connection to weight loss.
After my own struggle ....
After my own struggle with Saxenda and weight loss, I created my own plan wellness plan to help others lose weight. You can book a free 45-minute online wellness consultation with myself to see if my weight loss plan could help you kickstart your wellness journey. Yasmin
The middle of 2017 was the year that I started my Skinny Jab journey. I spent a whole year buying Saxenda - taking it on, off, on, off, binning it, giving up on it and starting all over again. This left me de-moralised, deflated, financially poorer and really, really miserable!
Feeling such a failure - that this FDA approved weight loss medication was not even working for me. I eventually created my own plan - by putting all the pieces of the jigsaw together. The Skinny Jab was part of the plan - but I stress it is not a magic wand, it helped me control my hunger pangs and cravings. But it was not the whole story.
It was successful in helping me lose weight combined with other factors. I lost three stone in weight and took control of my life again, you can do the same!
Yasmin - founder of the Kickstarter Plan and Skinni Jab